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A prospective study was performed on neurosurgical samples from 18 patientsto evaluate the use of Full-Field Optical Coherence Tomography (FF-OCT) inbrain tumor diagnosis. FF-OCT captures en face slices of tissue samples at1\mum resolution in 3D with a typical 200\mum imaging depth. A 1cm2 specimen isscanned at a single depth and processed in about 5 minutes. This rapid imagingprocess is non-invasive and 30 requires neither contrast agent injection nortissue preparation, which makes it particularly well suited to medical imagingapplications. Temporal chronic epileptic parenchyma and brain tumors such asmeningiomas, low- grade and high-grade gliomas, and choroid plexus papillomawere imaged. A subpopulation of neurons, myelin fibers and CNS vasculature wereclearly identified. Cortex could be discriminated from white matter, butindividual glial cells as astrocytes (normal or reactive) or oligodendrocyteswere not observable. This study reports for the first time on the feasibilityof using FF-OCT in a real-time manner as a label-free non-invasive imagingtechnique in an intra-operative neurosurgical clinical setting to assesstumorous glial and epileptic margins.

Imaging of non tumorous and tumorous human brain tissue with full-field optical coherence tomography