English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

A detailed understanding of the interface between living cells and substratematerials is of rising importance in many fields of medicine, biology andbiotechnology. Cells at interfaces often form epithelia. The physical barrierthat they form is one of their main functions. It is governed by the propertiesof the networks forming the cytoskeleton systems and by cell-to-cell contacts.Different substrates with varying surface properties modify the migrationvelocity of the cells. On the one hand one can change the materialscomposition. Organic and inorganic materials induce differing migrationvelocities in the same cell system. Within the same class of materials, achange of the surface stiffness or of the surface energy modifies the migrationvelocity, too. For our cell adhesion studies a variety of different,homogeneous substrates were used (polymers, bio-polymers, metals, oxides). Inaddition, an effective lithographic method, Polymer Blend Lithography (PBL), isreported, to produce patterned Self-Assembled Monolayers (SAM) on solidsubstrates featuring two or three different chemical functionalities. This weachieve without the use of conventional lithography like e-beam or UVlithography, only by using self-organization. These surfaces are decorated witha Teflon-like and with an amino-functionalized molecular layer. The resultingpattern is a copy of a previously created self-organized polymer pattern,featuring a scalable lateral domain size in the sub-micron range down below 100nanometers. The resulting monolayer pattern features a high chemical andbiofunctional contrast with feature sizes in the range of cell adhesioncomplexes like e.g. focal adhesion points.

Interaction of Epithelial Cells with Surfaces and Surfaces Decorated by Molecules