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In this work we consider how surface-adherent bacterial biofilm communitiesrespond in flowing systems. We simulate the fluid-structure interaction andseparation process using the immersed boundary method. In these simulations wemodel and simulate different density and viscosity values of the biofilm thanthat of the surrounding fluid. The simulation also includes breakable springsconnecting the bacteria in the biofilm. This allows the inclusion of erosionand detachment into the simulation. We use the incompressible Navier-Stokes(N-S) equations to describe the motion of the flowing fluid. We discretize thefluid equations using finite differences and use a geometric multigrid methodto solve the resulting equations at each time step. The use of multigrid isnecessary because of the dramatically different densities and viscositiesbetween the biofilm and the surrounding fluid. We investigate and simulate themodel in both two and three dimensions.  Our method differs from previous attempts of using IBM for modelingbiofilm/flow interactions in the following ways: the density and viscosity ofthe biofilm can differ from the surrounding fluid, and the Lagrangian nodelocations correspond to experimentally measured bacterial cell locations from3D images taken of Staphylococcus epidermidis in a biofilm.

Spatially Heterogeneous Biofilm Simulations using an Immersed Boundary Method with Lagrangian Nodes Defined by Bacterial Locations