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Extremely low frequency electromagnetic fields aren't considered as a realcarcinogenic agent despite the fact that some studies have showed impairment ofthe DNA integrity in different cells lines. The aim of this study wasevaluation of the late effects of a 100 Hz and 5.6 mT electromagnetic field,applied continuously or discontinuously, on the DNA integrity of Vero cellsassessed by alkaline Comet assay and by cell cycle analysis. Normal Vero cellswere exposed to extremely low frequency electromagnetic fields (100 Hz, 5.6 mT)for 45 minutes. The Comet assay and cell cycle analysis were performed 48 hoursafter the treatment. Exposed samples presented an increase of the number ofcells with high damaged DNA as compared with non-exposed cells. Quantitativeevaluation of the comet assay showed a significantly ($<$0.001) increase of thetail lengths, of the quantity of DNA in tail and of Olive tail moments,respectively. The analysis of the registered comet indices showed that anextremely low frequency electromagnetic field of 100 Hz and 5.6 mT had agenotoxic impact on Vero cells. Cell cycle analysis showed an increase of thefrequency of the cells in S phase, proving the occurrence of single strandbreaks. The most probable mechanism of induction of the registered effects isthe production of different types of reactive oxygen species.

Extremely low-frequency electromagnetic fields cause DNA strand breaks in normal Vero cells