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Mutual information in three (or more) dimensions can be considered as aTriple-Helix indicator of synergy in university-industry-government relations.An open-source routine th4.exe makes the computation of this indicatorinteractively available at the Internet, and thus applicable to large sets ofdata. Th4.exe computes all probabilistic entropies and mutual information intwo, three, and, if available in the data, four dimensions among, for example,classes such as geographical addresses (cities, regions), technological codes(e.g., OECD's NACE codes), and size categories; or, alternatively, amonginstitutional addresses (academic, industrial, public sector) in document sets.The relations between the Triple-Helix indicator -- as an indicator of synergy-- and the Triple-Helix model that specifies the possibility of feedback by anoverlay of communications, are also discussed.

A Routine for Measuring Synergy in University-Industry-Government Relations: Mutual Information as a Triple-Helix and Quadruple-Helix Indicator