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Trypanosoma cruzi and Giardia intestinalis are two human pathogens andprotozoan parasites responsible for the diseases Chagas disease and giardiasis,respectively. Both diseases cause suffering and illness in several millionindividuals. The former disease occurs primarily in South America and CentralAmerica, and the latter disease occurs worldwide. Current therapeutics aretoxic and lack efficacy, and potential vaccines are far from the market.Increased knowledge about the biology of these parasites is essential for drugand vaccine development, and new diagnostic tests. In this thesis,high-throughput sequencing was applied together with extensive bioinformaticanalyses to yield insights into the biology and evolution of Trypanosoma cruziand Giardia intestinalis. Bioinformatics analysis of DNA and RNA sequences wasperformed to identify features that may be of importance for parasite biologyand functional characterization. This thesis is based on five papers (i-v).Paper i and ii describe comparative genome studies of three distinct genotypesof Giardia intestinalis (A, B and E). Paper iii describes a genome comparisonof the human infecting Trypanosoma cruzi with the bat-restricted subspeciesTrypanosoma cruzi marinkellei. Paper iv describes the repertoire of smallnon-coding RNAs in Trypanosoma cruzi epimastigotes. Paper v describestranscriptome analysis using paired-end RNA-Seq of three distinct genotypes ofGiardia intestinalis (A, B and E).

Genome and transcriptome studies of the protozoan parasites Trypanosoma cruzi and Giardia intestinalis