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LAGE is a systematic framework developed in Java. The motivation of LAGE isto provide a scalable and parallel solution to reconstruct Gene RegulatoryNetworks (GRNs) from continuous gene expression data for very large amount ofgenes. The basic idea of our framework is motivated by the philosophy ofdivideand-conquer. Specifically, LAGE recursively partitions genes intomultiple overlapping communities with much smaller sizes, learnsintra-community GRNs respectively before merge them altogether. Besides, thecomplete information of overlapping communities serves as the byproduct, whichcould be used to mine meaningful functional modules in biological networks.

LAGE: A Java Framework to reconstruct Gene Regulatory Networks from Large-Scale Continues Expression Data