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The theoretical case is considered where the total amount of plasma proteinis conserved, but the drug is eliminated after its single application. After asingle drug application at time t = 0, the total drug concentration is measuredat times ti,...,tk and the total drug concentration at time ti is denoted by{\phi}i. Our discussion is limited to one protein binding site. The quantity ofplasma protein ({\Lambda}), the association constant (Ka) and the totalconcentration of the drug {\phi}i at time ti are considered as independentvariables. Free drug concentration, plasma protein bound concentration and freedrug fraction are given as functions of these "new" variables. The aim of thiscommunication is to derive the formula that allows to calculate the free drugconcentration at any time after the drug application, based on 3 parameters:the association constant of the drug, the total plasma concentration of thedrug and the concentration of the protein. If the plasma protein quantity({\Lambda}) and the association constant (Ka) are known, then from theknowledge of the total drug concentration {\phi}i at time ti it is possible todetermine the free drug concentration at time ti.

On the Way to More Convenient Description of Drug-Plasma Protein Binding