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Matrix tablets are drug delivery devices designed to release a drug in acontrolled manner over an extended period of time. We develop a cellularautomaton (CA) model for the dissolution and release of a water-soluble drugand excipient from a matrix tablet of water-insoluble polymer. Cells of the CAare occupied by drug, excipient, water or polymer and the CA updating rulessimulate the dissolution of drug and excipient and the subsequent diffusion ofthe dissolved substances. In addition we simulate the possible fracture ofbrittle drug and excipient powders during the tablet compression and themelting of the polymer during a possible thermal curing process. Differentstirring mechanisms that facilitate the transport of dissolved drug in thefluid in which the tablet is immersed are modeled in the water cells adjacentto the boundary of the tablet. We find that our simulations can reproduceexperimental drug release profiles. Our simulation tool can be used tostreamline the formulation and production of sustained release tablets.

Swallowing a cellular automaton pill: predicting drug release from a matrix tablet