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Fifty cases of breast carcinoma were investigated for Nm23, LPA1, Ki67 andp53 antigen expression, using immunohistochemical techniques. Correlationbetween markers was studied. Nm23 showed an inverse correlation with LPA1 andKi67, and positive with p53. Nm23/LPA1presented significant (p<0.001) negativecorrelation with p53, but not difference were observed with Ki67. It can beconcluded that: 1) Nm23 and LPA1 tend to be inversely correlated; 2) Nm23correlates positively with p53, regardless of tumour type and patient'shormonal status; 3) Nm23 shows a reverse trend in comparison with Ki67.However, more studies are needed to determinate if hormone receptors play somerole in the inverse relationship between Nm23-LPA1 and to know the tumour typeimplication in these relationships.

Immunoexpression of Nm23: correlation with traditional prognostic markers in breast carcinoma