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Electrohydrodynamic (EHD) generation, a commonly used method in BioMEMS,plays a significant role in the pulsed-release drug delivery system for adecade. In this paper, an EHD based drug delivery system is well designed,which can be used to generate a single drug droplet as small as 2.83 nL in 8.5ms with a total device of 2x2x3 mm^3, and an external supplied voltage of 1500V. Theoretically, we derive the expressions for the size and the formation timeof a droplet generated by EHD method, while taking into account the drug supplyrate, properties of liquid, gap between electrodes, nozzle size, and chargeddroplet neutralization. This work proves a repeatable, stable and controllabledroplet generation and delivery system based on EHD method.

Calculation of Droplet Size and Formation Time in Electrohydrodynamic Based Pulsatile Drug Delivery System