English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

Glioblastoma is a rapidly evolving high-grade astrocytoma that isdistinguished pathologically from lower grade gliomas by the presence ofnecrosis and microvascular hiperplasia. Necrotic areas are typically surroundedby hypercellular regions known as "pseudopalisades" originated by local tumorvessel occlusions that induce collective cellular migration events. This leadsto the formation of waves of tumor cells actively migrating away from centralhypoxia. We present a mathematical model that incorporates the interplay amongtwo tumor cell phenotypes, a necrotic core and the oxygen distribution. Oursimulations reveal the formation of a traveling wave of tumor cells thatreproduces the observed histologic patterns of pseudopalisades. Additionalsimulations of the model equations show that preventing the collapse of tumormicrovessels leads to slower glioma invasion, a fact that might be exploitedfor therapeutic purposes.

Hypoxic Cell Waves around Necrotic Cores in Glioblastoma: A Biomathematical Model and its Therapeutic Implications