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Multiple perspectives on the nonlinear processes of medical innovations canbe distinguished and combined using the Medical Subject Headings (MeSH) of theMedline database. Focusing on three main branches-"diseases," "drugs andchemicals," and "techniques and equipment"-we use base maps and overlaytechniques to investigate the translations and interactions and thus to gain abibliometric perspective on the dynamics of medical innovations. To this end,we first analyze the Medline database, the MeSH index tree, and the variousoptions for a static mapping from different perspectives and at differentlevels of aggregation. Following a specific innovation (RNA interference) overtime, the notion of a trajectory which leaves a signature in the database iselaborated. Can the detailed index terms describing the dynamics of research beused to predict the diffusion dynamics of research results? Possibilities arespecified for further integration between the Medline database, on the onehand, and the Science Citation Index and Scopus (containing citationinformation), on the other.

Bibliometric Perspectives on Medical Innovation using the Medical Subject Headings (MeSH) of PubMed