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The theory describing action of medicines explored in this paper is based onassumption that vital activity of the cell may be described in terms of themodel of two states: resting state and excitation. According to availablephysiological data excitation state is dangerous for cell and may causedifferent pathological changes, including "conformational" diseases, due toprotein aggregation. Normally, the excitation is completely reversible and thekey role is played here by ATP (adenosine-5'-triphosphate) which disaggregatesproteins of cytomatrix. The same effect ATP exerts during cell injury byeliciting a "healing" effect. Damage of cell structures we consider as"illness", whereas removal of pathological consequences caused by proteinaggregation of any origin we will call "a cure". The latter is considered asphysical process of cell recovering from excitation/injury to resting state,which is analyzed in terms of our generalized thermodynamics. "Cure" results inreduction of effective temperature of cell proteins due to bindingintracellular water which is present in the cell at concentration ofapproximately 44 M. As a result of the sorption processes mobility of bothwater and proteins is greatly reduced, and the corresponding reduction of theeffective temperature seen by us as a measure of treatment effect.

Thermodynamics of pharmacological action for electron-accepting  compounds on activated or damaged cell in the context of Ling's model of the  living cell