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Voltage clamp data were analyzed in order to characterize the properties ofthe fast potassium transient current IA for a serotonergic neuron of the ratdorsal raphe nucleus (DRN). We obtain maximal conductance, time constants ofactivation and inactivation, and the steady state activation and inactivationfunctions, as Boltzmann curves, defined by half-activation potentials and slopefactors. We employ a novel method to accurately obtain the activation functionand compare the results with those obtained by other methods. The form of IA isestimated as g(V-V_{rev}) m^4h with g=20.5 nS. For activation, thehalf-activation potential is V_a=-52.5 mV with slope factor k_a=16.5 mV,whereas for inactivation the corresponding quantities are -91.5 mV and -9.3 mV.We discuss the results in terms of the corresponding properties of \IA in othercell types and their possible relevance to pacemaking activity in 5-HT cells ofthe DRN.

Properties of IA in a serotonergic neuron of the dorsal raphe nucleus