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In this paper, we consider the 1D Navier-Stokes equations for viscouscompressible and heat conducting fluids (i.e., the full Navier-Stokesequations). We get a unique global classical solution to the equations withlarge initial data and vacuum. Because of the strong nonlinearity anddegeneration of the equations brought by the temperature equation and byvanishing of density (i.e., appearance of vacuum) respectively, to our bestknowledge, there are only two results until now about global existence ofsolutions to the full Navier-Stokes equations with special pressure, viscosityand heat conductivity when vacuum appears (see \cite{Feireisl-book} where theviscosity $ \mu=$const and the so-called {\em variational} solutions wereobtained, and see \cite{Bresch-Desjardins} where the viscosity $ \mu=\mu(\rho)$degenerated when the density vanishes and the global weak solutions were got).It is open whether the global strong or classical solutions exist. By applyingour ideas which were used in our former paper \cite{Ding-Wen-Zhu} to get$H^3-$estimates of $u$ and $\theta$ (see Lemma \ref{non-le:3.14}, Lemma\ref{non-le:3.15}, Lemma \ref{non-rle:3.12} and the corresponding corollaries),we get the existence and uniqueness of the global classical solutions (seeTheorem \ref{non-rth:1.1}).

Global Classical Large Solutions to Navier-Stokes Equations for Viscous Compressible and Heat Conducting Fluids with Vacuum