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The invention of laser immediately enabled us to detect nonlinearities ofphoton interaction in matter, as manifested for example by Franken et al.'sdetection of second harmonic generation and the excitation of the Brillouinforward scattering process. With the recent advancement in high power highenergy laser and the examples of the nonlinearity study of laser-matterinteraction by virtue of properly arranging laser and detectors, we envisionthe possibility of probing nonlinearities of photon interaction in vacuum oversubstantial spacetime scales compared with the microscopic scale provided byhigh energy accelerators. The hithertofore never detected Euler-Heisenbergnonlinearities in quantum electrodynamics (QED) in vacuum should come withinour reach of detection using intense laser fields. Also our method should putus in a position with a far greater sensitivity of probing possible light-massfields that have been postulated. With the availability of a large number ofcoherent photons our suggested measurement methods include the phase sensitive(contrast) imaging that avoids the pedestal noise and the scheme of secondharmonic detection of photon nonlinearities in vacuum over a longco-propagating distance incurring resonance excitation. These methods carve outa substantial swath of new experimental parameter regimes of the exploration ofphoton nonlinearities in vacuum covering the force range from the electron massscale to below neV.

Probing semi-macroscopic vacua by high fields of lasers