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Suppose M is a non-compact connected n-manifold without boundary, DD(M) isthe group of C^\infty-diffeomorphisms of M endowed with the WhitneyC^\infty-topology and DD_0(M) is the identity connected component of DD(M),which is an open subgroup in the group DD_c(M) \subset DD(M) of compactlysupported diffeomorphisms of M. It is shown that DD_0(M) is homeomorphic to N\times IR^\infty for an l_2-manifold N whose topological type is uniquelydetermined by the homotopy type of DD_0(M). For instance, DD_0(M) ishomeomorphic to l_2 \times IR^\infty if n = 1, 2 or n = 3 and M is orientableand irreducible. We also show that for any compact connected n-manifold N withnon-empty boundary \partial N the group DD_0(N - \partial N) is homeomorphic toDD_0(N; \partial N) \times IR^\infty, where DD_0(N;\partial N) is the identitycomponent of the group DD(N;\partial N) of diffeomorphisms of N that do notmove points of the boundary \partial N.

Diffeomorphism groups of non-compact manifolds endowed with the Whitney C^infty-topology