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Much interest has been generated for biotechnological methods in the production of polysaccharides that can be applied within the food, pharmaceutical, cosmetic, and other industries. The majority of polysaccharides with various physiological activities are frequently derived from fungi, especially mushrooms (Yu et al. 2005; Yoon et al. 2008). Some of these polysaccharides, such as Lentinan from Lentinus edodes fruit bodies, Schizophyllan from Schizophyllum commune culture filtrates, Grifolan from Grifola frondosa, and polysaccharide-K (PSK) from Coriolus versicolor culture mycelia, are now used in clinics (Fisher & Yang 2002; Isoda et al. 2009). Moreover, polysaccharides from mushrooms enhance and stimulate the immune system of humans and mice, and are thus called biological response modifiers (BRMs) (Yoon et al. 2008; Deng et al. 2009).Hericium erinaceum (bearded tooth mushroom) is a traditional edible mushroom that grows on both living and dead broad leaf

Immune Enhancement of Hericium erinaceum Mycelium Cultured in Submerged Medium Supplemented with Ginseng Extract