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B 1 (thiamin), B 2 (riboflavin), B 3 (nicotinic acid and nicotine amide), B 6 (pyridoxine), C(ascorbic acid)  .  ,  ,  ,  4  27  , Ion-pair  HPLC-UVD   .  B 1 , B 2 , B 3 , B 6 , C  HPLC  ,  0.02% triethylamine, 17.5%  , 5 μM sodium hexanesulfonic acid  pH 3.5(acetic acid  )  ,  30  .  96%  .  ,  ,  ,  USP  ICH  HPLC  .  ,  HPLC  .  20  .  . Key words: dietary supplement, water-soluble vitamin, simultaneous determination, HPLC † Corresponding author: So Hee Kim, National Institute of Food and Drug Safety Evaluation, Cheongwon 363-951, Korea. Tel: +82-43-719-4351, Fax: +82-43-719-4352, E-mail: mrsksh@kfda.go.kr

han'gug sigpum yeong'yang haghoeji/han-guk sikpum yeong-yang hakoeji

Simultaneous Determination of Water-Soluble Vitamins (Vitamin B1, B2, B3, B6and C) in Dietary Supplements by High-Performance Liquid Chromatography