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4,5-dibromoimidazole (DBI) was synthesized and its structure elucidated using H-NMR, C-NMR, FT-IR and mass spectroscopy. Its activity on Streptococcus pyogenes, Staphylococcus aureus, Pseudomonas aeruginosa, Proteus spp, Aspergillus spp, Candida spp and Trichophyton spp was studied for possible antimicrobial properties. The compound showed no activity on Pseudomonas aeruginosa, Proteus spp, Aspergillus spp and Candida spp. while Streptococcus pyogenes and Staphylococcus aureus were slightly sensitive to it. The potency of this compound on these organisms was shifted by its transition metal complexes. A five to six fold enhancement in activity was observed with its Co complex which remained potent even at lower concentrations. Cr 3+ and Cu 2+ complexes of the compound at higher concentrations showed a similar increase in sensitivity as the Co complex. The Fe complex of the compound however rendered the compound totally inactive against all the studied organisms.

Enhancement of the Bioactivity of 4, 5-dibromoimidazole by its Cobalt (II) Complex