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We present a rapid, efficient one pot synthesis of [1,2,4]triazolo [5,1-b]quinazolin8(4H)-one derivatives by condensation of 3-amino-1,2,4-triazole with aldehydes and dimedone in the presence of boric acid (5 mmol%) as a catalyst. This protocol corresponds in short reaction time, low cost, high reaction yield, no need of chromatographic separation with green aspects by using water soluble catalysts.

Boric acid catalyzed one-pot synthesis of [1,2,4] triazolo quinazolinone Derivatives