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The antimicrobial activity of synthesized 6-chloro-2-methyl-1H-carbazole-1,4(9H)-dione and 6- chloro-3-methyl-1H-carbazole-1,4(9H)-dione were studied against Escherichia coli (MTCC 42), Bacillus subtilis (MTCC 121), Staphylococcus aureus (MTCC 96), methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas sp.(MTCC 6199). 6-Chloro-2-methyl-1H-carbazole-1,4(9H)-dione having methyl substituent at C-2 and electron withdrawing chloro group at C-6 exhibited the remarkable antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) with MIC value of 50 µg/mL and against Staphylococcus aureus (MTCC 96) with MIC value of 100 µg/mL. However, 6-chloro-3-methyl-1H-carbazole-1,4(9H)-dione bearing methyl substituent at C-3 with chloro group at C-6 does not exhibited any antimicrobial activity against these pathogenic bacteria.

In Vitro Activity of Synthesized 6-Chloro-2-methyl-1H-carbazole- 1, 4(9H)-dione against Methicillin-Resistant Staphylococcus aureus