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Cardiovascular disease remains the major cause of morbidity and death in developed countries, claiming 17.1 million lives a year. Tobacco use, an unhealthy diet, physical inactivity and harmful use of alcohol increase the risk of heart attacks and strokes .Atherosclerosis (also known as arteriosclerotic vascular disease or ASVD) is the condition in which an artery wall thickens as the result of a build-up of fatty materials such as cholesterol. Though statins drugs are widely used for the treatment of atherosclerosis it also causes many side effects likes liver failure, rhabdomyolysis kidney failure etc. In this paper, we summarized the in silico methods used to enhance the understanding of Lanosterol synthase, particularly in its binding site, to design new drug molecules for the inhibition of cholesterol biosynthesis. Several computational methods such as docking approaches, molecular dynamics studies, quantum mechanical studies, among other physicochemical methods that exhibit quantitative structure-activity relationships have been used for this purpose.

In Silico Development For Cholesterol Management-By The Inhibition Of Lanosterol Synthase