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Severe acute liver failure (ALF) manifests itself as a rare syndrome, with multiple etiologies for similar clinical conditions. Melatonin (MLT) is a lipophilic indolamine that is synthesized in the pineal gland from serotonin. This study was designed to evaluate hepatic changes resulting from the thioacetamide-induced ALF model, as well as the effects of MLT treatment in male Wistar rats (n = 56) in 24and 48-h experiments. The results indicate a hepatoprotective effect of MLT, with no difference between the studied times, and increased animal survival.

Action of Melatonin on Severe Acute Liver Failure in Rats