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The present work was designed to evaluate the role of pine bark extract (PBE) in protecting rats from oxidative stress produced by recurrent hypoglycemia. The animals were grouped as the following: control group, PBE-treated group (treated with 150 mg/ kg b wt; daily via oral gavage for 30 consecutive days); recurrent hypoglycemia group (injected with 1.14 units of insulin/ kg b wt; day after day subcutaneously, for 30 days) and recurrent hypoglycemia & PBE-treated group (the rats received PBE and insulin as in group 2 and group 3, respectively). Serum glucose and total proteins (TP) as well as liver and brain glycogen contents were significantly decreased when compared with both control and PBE-treated groups but, they were increased significantly when compared with recurrent hypoglycemia group.Whereas serum insulin and γ-Glutamyl transferase (γ-GT) activity were increased when compared with both control and PBE-treated groups. Liver and brain total antioxidant capacity (TAC) as well as, superoxide dismutase (SOD), catalase (CAT) and glutathiones-transferase (GST) activities were significantly decreased when compared with both control and PBE-treated groups. Whereas, malonedialdehyde (MDA) levels of both liver and brain tissues were increased significantly when compared with both control and PBE-treated groups. Liver glutathione (GSH) content showed significant decrease whereas, brain GSH showed insignificant change.

Pine Bark Extract Protects Against Oxidative Stress Induced By Recurrent Hypoglycemia In Rats.