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Nerium oleander is an evergreen shrub of Apocynaceae family cultivated worldwide as an ornamental plant. All parts of the plant are toxic and contain a mixture of very toxic cardiac glycosides of cardenolides. albino mice were divided into four groups. group I was normal control group; and others represented three concentration from steroid component of Nerium oleander (0.003,0.006 and 0.012 mg/kg). Liver marker enzymes were assayed in serum. Levels of marker enzymes such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were increased significantly. Sections of livers were observed under microscope for the histopathological changes such as destruction of the liver architecture with increased inflammation was observed compared with control.

The Effect of Steroidal Extract of Nerium oleander on the Liver Tissue Structure of Albino Mice