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Studies have acknowledged improved intraocular pressure results with topical pressure lowering drugs. However, paucity of literature exists among theNigerian population and among South South inhabitance in particular. It is the aim of this study to investigate and compare the efficacy of timolol and latanoprost among patients attending the Ophthalmic Clinic of Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.In a bid to achieve this objective, arandomized control trial was conducted from January 2014 to December 2014 involving patients with ocular hypertension. Patients were enrolled over a period of 12 weeks and followed up in 8 clinic visits over a 30 week period.A total of 104 patients completed the study (52 in timolol group and 52 in latanoprost group). The mean baseline intraocular pressures were 24.52mmHg in timolol group and 26.71mmHg in latanoprost group. Both drugs showed intraocular pressure (IOP)reducing potentials with mean percentage reduction of 34.14% (-8.37) and 40.02% (-10.69) respectively at the end of the study. Based on the results of this study, latanoprostprovides better IOP lowering effect among inhabitance around Irruaand environs.

iosr journal of pharmacy and biological sciences

Comparative Efficacy of Timolol and Latanoprost on Intraocular Hypertension Among Patients Attending the Ophthalmic Clinic of Irrua Specialist Teaching Hospital, Irrua, Nigeria