English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

A sensitive and specific liquid chromatography combined with electrospray ionization (ESI) tandem mass spectrometry (LC-MS/MS) method, operating in the positiveionization mode, for quantifying of milnacipran in human plasma using milnacipran-d10 as internal standard (IS) was developed and validated. The analyte and IS were extracted by simple one step protein precipitation (PP). The chromatographic separation was performed on a Gemini C18 column (150 X 2.0 mm, 5 um) under isocratic conditions using a mixture of acetonitrile/0.1% formic acid (50:50, v/v) as mobile phase at a flow rate of 0.25 ml/min. Quantitation was performed using multiple reaction monitoring (MRM) mode to study parent → product ion transitions of m/z 247.2 →100.1 for milnacipran and m/z257.2→240.3 for IS, respectively. Linearity in plasma was obtained over the concentration range 2 ~ 500 ng/ml, with a coefficient of determination (r 2 ) of 0.9999. The method was has

iosr journal of pharmacy and biological sciences

Validated Liquid Chromatography-Electrospray Ionization Tandem Mass Spectrometric Method for Quantification of Milnacipranin Human Plasma for Pharmacokinetic Study: ARandomized, Open-Label, Two-Period, Comparative Crossover Study in Healthy Korean Male Volunteers