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The objective of this study was to assess the prevalence of neuron and hepatotoxicity of Methotrexate (MTX) and prophylactic response to Ca- Folinate (Ca-F) and Ginseng (G). Forty two of male albino rat were divided to seven groups six rats for each. 1 st control group received 1ml saline i.p daily for 4weeks (C), 2 nd group treated with Ca-F (5 mg /kg b.wt i.p.) for 4 weeks. 3 rd group treated with G (25 mg /kg b.wt orally) for 4 weeks. 4 th group treated with MTX (0.45 mg /kg b.wt i.p.) for 4 weeks. 5 th group treated with MTX + Ca-F (0.45 mg/kg and 5 mg/ kg i.p.) for 4 weeks, respectively. 6 th group treated with MTX + G (0.45 mg/kg and 25 mg/ kg i.p.) for 4 weeks, respectively. 7 th group treated with MTX + Ca-F + G (0.45 mg/kg, 5 mg/kg and 25 mg/ kg i.p) for 4 weeks, respectively. In this study, aspartic acid (ASP), glutamic acid (GLU), ALT, AST, γ-GT, MDA, GSSG and NO were increase (P< 0.05) in MTX group comparing with control group in rat brain. Glycine (GLY), γ amino butyric acid (GABA), Norepinephrine (NE), Dopamine (DA), serotonin (5TH) and GSH were decrease (P< 0.05) in MTX group comparing with control group in rat brain. All these parameters were improved with G, F and there combination comparing with MTX group. Histopathological examination showed ameliorates effect for all treatments against MTX pathogenesety. It could be concluded that F and G influences and regeneration of neurons amino acids and catecholamine's activity and decrease liver enzymes and oxidative stress markers.

Protective Effect of Ca- Folinate and Ginseng in Male Rats Treated with Methotrexate