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The effect of shaddock citrus fruit juice on the lipid profile, fasting blood glucose level and some kidney function markers were evaluated in 16 male Wistar albino rats. The rats were procured from Faculty of Veterinary Medicine, Animal House, University of Nigeria, Nsukka and were of average age of 12 weeks, weighing 130 – 170grams. The rats were acclimatized for 7days and randomly separated into 2 groups of eight rats each, kept in 2 different standard cages. The groups were as follows: A – rats fed with rat feed (Control), B – rats fed with rat feed and shaddock citrus fruit juice. At the end of 28days feeding experiment, the rats were bled and blood collected were used for lipid profile, fasting blood glucose level and kidney function assays using standard biochemical methods. The results of the study indicated a decrease in the blood glucose level of rats supplemented with shaddock citrus fruit juice (group B) when compared with those of the control (group A). Result of the study also showed significant reduction (p<0.05) in mean total cholesterol, low density lipoprotein (LDL) and triglyceride concentrations of rats supplemented with shaddock citrus fruit juice when compared with those of the control. Moreover, the result revealed no significant difference (p>0.05) in mean urea and creatinine concentrations of rats supplemented with shaddock citrus fruit juice when compared with those of the control. The result of this study suggests that shaddock citrus fruit juice was not toxic to the kidney and could assist in reducing the blood glucose level and protect against cardiovascular diseases and related complications.

Effect of Shaddock Citrus Fruit Juice on the Lipid Profile, Fasting Blood Glucose Level and Kidney Function of Male Wistar Albino Rats