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Effectiveness of many antibiotics has been remarkably decreased due to bacterial resistance. the present work aims to explore a novel antimicrobial nanocomposite with greater efficacy against resistant bacteria. Tobramycin-silver nanocomposite was synthesized and characterized by Transmission Electron Microscopy, UV-VIS Spectroscopy, Zetasizer and Fourier Transform Infrared spectroscopy. Antimicrobial activity of tobramycin, silver nanoparticles and Tobramycin-silver nanocomposite was tested against Staphylococcus aureus, pseudomonas aurignosa, Klebsiella pneumonia, Proteus mirabilis and acinetobacter bauminaii, the results revealed that Tobramycin-silver nanocomposite had enhanced antimicrobial efficacy against the selected resistant strains in range between 250% and 980% than Tobramycin alone.

Tobramycin-Silver Nanocomposite: A New Trend of Antimicrobials against Resistant Strains