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The present research was focused to evaluate the antidiabetic activity of ethanolic and methanolic leaf extractsof Curcuma inodora in streptozotocin -induced diabetic rats. Ethanolic and methanolic leaves extract of Curcuma inodora (100,200,400 mg/kg) were administered to streptozotocin -induced diabetic rats for 14 day and blood glucose levels were estimated daily at regular intervals up to 14 days through out the treatment using Glucose peroxidation method. Treatment of streptozotocin induced diabetic rats with ethanolic leaf extract of Curcuma inodora caused a significant decrease in blood glucose levels at a dose of 200mg/kg and 400mg/kg when compared with standard glibenclamide drug . Treatment of streptozotocin induced diabetic rats with Methanolic leaf extracts of Curcuma inodora caused less significant decrease in blood glucose levels at a dose of 200 & 400mg/kg when compared with standard glibenclamide drug .The maximum reduction in the blood glucose was observed 6th hour to 10th hour after oral administration of 200 and 400mg/kg b.w of ethanolic extracts of leaves of curcum a inodora . These results suggest that ethanolic leaf extract of cururma inodora reduced elevated blood glucose levels more significantly compared to methanolic leaf extract in streptozotocin induced diabetic rats in a dose dependent manner .

Evaluation of anti-diabetic activty of ethanolic and methanolic extracts of leaves of curcuma inodora against streptozotocin induced diabetic rats