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Leishmaniasis is a generally neglected disease, particularly in terms of new drug development for which there is little potential for financial return. Although there have been significant advances in treatment for leishmaniasis in the past decade, these developments cannot match the scale of more profitable drugs, more so that the attendant high toxicity and side effects associated with the conventional orthodox supplements left much to be desired. HEPATOSAAB, an ethnomedicinal poly herbal formulation from the stable of Halamin Herbal Centre has been found to cure Visceral Leishmaniasis which works by inducing high levels of certain cytokines to positively affect macrophage populations and up-regulates the expression of MHC class II molecules on the surface of the macrophage. It is clearly demonstrated that this inexpensive, simple, effective and non toxicethnomedicinal poly herbal formulation has a promising curative role in the treatment of Visceral Leishmaniasis. The real challenge now will be proper translation, distribution and expansion of the advances made; it is essential that the new treatment options become truly accessible, not simply available, in endemic areas so that they may promote healing and save lives. Keyword: Hepatosaab, Leishmaniasis, MHC class II, Ethnomedicinal

Ethnopharmacological and Precliical Studies on Hepatosaab Used In the Management of Leishmaniasis