English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Memory impairment is the major concern of antiepileptic therapy. This study was undertaken to evaluate the memory impairment potential of Pregabalin (PGBL) and to assess the protective effect of hydro alcoholic extract of Ocimum sanctum leaves (OSHAE) and levetiracetam (LEV). Preliminary phytochemical screening and in-vitro antioxidant activity of OSHAE were done. Memory impairment induced by PGBL was evaluated by Morris water maze (MWM) test using mice as animal model. The animals were observed for Escape Latency Time (ELT) and Time Spent in Target Quadrant (TSTQ). OSHAE exhibited potent antioxidant and free radical scavenging activity. Chronic administration of PGBL was found to induce memory impairment by increasing ELT and decreasing TSTQ when compared to normal animals. Memory impairment of PGBL was restored significantly by co-administration of OSHAE and LEV along with potentiation of anticonvulsant activity of PGBL. PGBL alone treated animals have shown more acetylcholinesterase (AChE) level when compared with normal animals where as co-administration of OS and LEV produced a decrease in AChE levels when compared to vehicle and PGBL treated group. The above study can be used as a reference to correct antiepileptic drug (AED) induced memory impairment by co-administration of nootropics without compromising on its antiepileptic potential. Key-words: Levetiracetam, Memory impairment, Ocimum sanctum, Pregabalin

Protective effect of tulsi and levetiracetam on memory impairment induced by pregabalin on mice