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Aspirin is easily hydrolyzed by water and it is therefore produced by slugging, which is a time consuming process. This work was aimed at studying the effect of humidity on the physical properties of aspirin tablets produced by melt granulation in comparison with conventionally produced aspirin tablets. Goat fat (1 to 2% w/w) and carnauba wax (2 to 7.5% w/w) were the waxes used as granulating agents in the melt granulation technique. The granules were characterized and the ones with adequate flow were compressed to tablets of diameter 13.8± 0.1 mm and thickness 3.2 ± 0.1mm using a single punch tableting machine. Resulting tablets were evaluated and then stored under ambient humidity and 1% relative humidity and the effect of the storage on the physical properties of the tablets were analyzed monthly for two months duration. The bulk and tapped densities of the granules were between the ranges of 0.62 ± 0.00 - 0.71 ± 0.01 g/cm 3 and 0.77 ± 0.02 - 0.85 ± 0.00 g/cm 3 respectively. The angle of repose ranged from 26.96 ± 0.07 o - 39.21 ± 0.02 o , Carr's index between 10.34 ± 0.14 and 21.88 ± 0.01 and Hausner's ratio being in the range of 1.12 ± 0.05 - 1.28 ± 0.11. The resulting tablets displayed a good disintegration, having disintegration time ranging from 2.28 ± 0.12 - 5.30 ± 0.13 min. Tablet friability and tensile strength ranged from 1.09 ± 0.05 - 3.10 ± 0.01% and 0.02 ± 0.01 - 0.07 ± 0.00 MNm -2 respectively. After storage there was no change in tensile strength, however, there was a change in disintegration time and friability ranging from 0.46 ± 0.05 - 5.50 ± 0.08 min and 1.25 ± 0.01 - 3.50 ± 0.10% respectively. Melt granulation, which is a simpler method, had the least influence of humidity on the physical properties of aspirin tablets. Keywords: Aspirin, Humidity, Melt granulation, Physical properties, Slugging and Waxes.

Effect of Humidity on the Physical Properties of Aspirin Tablets Produced By Melt Granulation and Slugging Methods