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The present study examined the effects of artesunate –amodiaquine combination therapy on spatial memory and anxietyrelated behaviors in healthy Swiss mice. Neurobehavioural models used were the Y maze and elevated plus maze. Selected for the experiments were eighty adult mice weighing 20-25 g. Forty animals were used in each behavioral model; they were randomly assigned into five groups A, B, C, D and E. Group A served as control and received normal saline, groups B, C and D received artesunate (4 mg/kg), amodiaquine (10 mg/kg) and artesunateamodiaquine combination(4 mg/kg and10 mg/kg) respectively while group E animals were given diazepam (5mg/kg). Drugs and vehicle were given orally for three days. The animals were exposed to the elevated plus maze (EPM) and the Y-maze on day 1 immediately after administering the first dose and day 3 immediately after the last dose, the number of entries and percentage time spent in the open and closed arms after five minutes’ exposure to the plus maze and Y–maze spontaneous alternations over a five minute period was scored for each animal. Statistical analysis was carried out using a one way ANOVA followed by a post-hoc test. Results of elevated plus maze tests revealed a significant increase in number of open arm entries and percentage time spent in the open arm and a significant reduction in the total number of arm entries compared to control; Y-maze task performance showed a significant reduction in percentage correct alternations compared to control .In conclusion artesunateamodiaquine administered over a three day period had anxiolytic and memory retarding effects in healthy mice thereby giving an insight into the possible behavioral effects in humans.

Oral Artesunate-Amodiaquine Combination Causes Anxiolysis and Impaired Cognition in Healthy Swiss Mice.