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Health concerns over pre-exposure prophylactic abuse of drugs have been reported. However, histological perspectives are not very common. This work is designed to investigate the morphological alteration of visceral organs (kidney and liver) of albino Wister rats pre-exposed to prophylactic consumption of sulfonamide based drugs. 30 albino rats of both sexes, with average weight of 198.50g were randomly selected into 4 treatment cages (A, B, C & D) and a Control cage (E) making a total of 6 rats per cage. Graded dose of Laridox were orally administered to the rats. Cages A-D received 1.0, 2.0, 3.0, 4.0 mg/kg body weight respectively. Cage E serves as the control group and received no drug treatment. Commercially purchased drinking water, standard top feed was given ad libitum, for 21 days. The animals were weighed before and after commencement of drug administration. Dullness and restlessness were observed and was carefully noted on all treated animals, but were marked in high dose treated animals in (Cages C and D). On day 22, the animals were sacrificed by cervical dislocation; gross examination was done and was quickly fixed in 10% buffered neutral formalin for routine histological study. Cut tissue at 3-5mm was processed according to paraffin embedding technique while section was cut at 3-5microns using haematoxylin and eosin method for light microscopy. Grossly, the organs of the high dose treatment animals in Cage C and D showed no apparent changes while histological findings after H&E method indicated that the treatment sections showed inflammatory cells, congested glomerulus, haematoma, thickening of the interstitial cells and vacuolation with congestive and tubular necrosis as compared to the control group. Decrease in body weights of the rats at the end of the study were statistically significant (p < 0.05) in the treatment groups B, C and D. Hence, this study shows that pre-exposure prophylactic consumption of sulfonamide based drugs used at a higher doses may have such cellular defects /adverse effects on the visceral organs of human in a similar circumstances.

Histological effects of pre-exposure prophylactic consumption of sulfa drugs on Liver and Kidney of albino Wister rats (Rattus novergicus).