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Recently, there have been growing concerns over the reliance and safety of untested and unregulated plant remedies. Brideliaferruginea is one of the herbal plants commonly used, of which chronic toxicity studies are yet to be examined. Sub-chronic toxicological effects of methanolicbenth bark extract of brideliaferruginea on biochemical indices in rats were evaluated. Three groups of six animals each were used in this study. Group 1 (control)received no treatment. Group 2 and 3 (treated)received calculated doses of 250mg/kg and 500mg/kg of the extract orally for four weeks. All animals were sacrificedusingdiethylether anesthesia 24hours after the last dosing and blood samples taken. Periodic weights and packed cells volume(PCV) were measured, portions of the heart and brain were excised, homogenized and used for bioassays. From our results, we observedsignificant decrease (p 0.05) was observed in heart and brain;reduced glutathione;catalase, also no effect was observed in lipid peroxidation of heart and brain. However, the two doses kept the weight constant for a period of four (4) weeks. Overall, thebark extract of brideliaferrugineamay affect antioxidant and blood status as well as keeping body weight constant. We suggest therefore thatdoses approaching or above 250mg/kg body weight should be avoided by individuals or in herbal preparations.

Sub-Chronic Effects of MethanolicBenth Bark Extract Of BrideliaFerrugineaon Some Selected Biochemical Indicesin Rats