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Fifty (50) patients clinically diagnosed as lymphoma patients, 17 (34%) Hodgkin's and, 33 (66%) patients Non Hodgkin ,attending Tumor Center in Merjan medical city, and (30 ) matched age person, as a control group enrolled in this study in the period between Junuary and Augest 2012. Specific diagnosis is clinically done by consultant physician, histopathologist and confirmed by specific marker or Cluster of Differentiation (CD) markers (CD20 and CD30), IL-8, and IFN-γ, estimated for all patients and control. The result shows that a highly significant (P<0.01) increased in IFNγ in both groups HL, and NHL, compared with control . IL-8 shows highly significant decreased (P<0.01) in result of NHL, compared with control, as well as no significant decreased of HL, in comparison with control. There is significant increased (P<0.05) in IL-8 level of HL patients compared with NHL. The Immunohistochemical result shows that highly association between CD20 with NHL, CD30 with HL. And it used specifically to confirm histopathological diagnosis of lymphomas. From present study can concluding the facts that, Activation of B and T cells in lymphoma patients lead to increased anti proliferating activity and immunomodulary of IFNγ, and in less extent IL-8 as chemotactic factor. Cytokines level important to monitored the severity of damage and whether the patients with good or bad prognosis. So that recommended to study other different types of cytokines for Th1, Th2, and NK cell activators to predict of ability to producing pro-inflammatory and anti-inflammatory mediators as well as ability to treatment of such diseases.

Determination of Chemoattractant factor (Interleukin -8) and Gamma interferon (IFN- γ) among Lymphoma patients (Hodgkin's and Non Hodgkin)