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Objective: To isolate Group A Streptococcal infection (GAS) from slum children in the age group of 5 to 10 years with or without evidence of throat infection dwelling in the slums of Chennai and to study their carrier state. Methods: Children aged between 5–15 years from slum were enrolled in this study. Socio demographic details were collected and their clinical examinations were done to identify symptoms. Two throat swabs were collected from all the children irrespective of symptoms. Bacterial culture was carried out in blood agar and the isolation of GAS was confirmed using hemolysis on blood agar, streptococcal group identification kit and bacitracin sensitivity. Blood sample was tested for ASO antibody titre. Findings: Group A streptococcus prevalence was isolated in 36% of slum population. Culture positive children were correlated with ASO antibody. Statistically significant correlation (p-value> 0.001) was observed between presence of antibody and culture positive. Recently infected children showed raised ASO antibody titre than the carrier. Major risk factors identified in GAS positive children were father’s occupation, type of house, number of windows and the unhygienic conditions of the slum. 36% were infected with Group A Streptococcal infection, 9% infected with Group C, 6% Group B, 1% Group D, 0.1 and 0.3 Group F and Group G streptococcal infection. Conclusion: The result shows that the prevalence of streptococcal infection was common among slum children but the prevalence of Group A streptococcus was high comparing to other groups of streptococcus. Socioeconomic status considered to be major associated risk factor for getting streptococcus infection.

iosr journal of pharmacy and biological sciences

Isolation and Identification of Group A Streptococcal Infection Among Slum Children in the Age Group of 5-15 Years in Chennai - One Year Prospective Study