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Two simple, accurate, sensitive and reproducible visible spectrophotometric methods (A & B) have been developed for the determination of Sitagliptin Phosphate (SGP) in bulk and also in pharmaceutical formulations. The proposed methods are based on complexation of the drug with Bromo Thymol Blue (BTBMethod A) & Bromo Cresol Green (BCG-Method B), extracted with chloroform, showing absorbance maxima at 412 nm and 419 nm respectively. Beer's law is obeyed over a concentration range of 25-125 μg/ml and 10-50 μg/ml respectively. Results of analysis for the two methods established, were validated statistically and also by recovery studies. All the variables were studied to optimize the reaction conditions. No interference was observed in the presence of common pharmaceutical excipients. The validity of the methods was tested by analyzing the drug in its pharmaceutical preparations. Good recoveries were obtained. The developed methods employed were successful for the determination of Sitagliptin Phosphate in various pharmaceutical preparations.

New Extractive Method Development of Sitagliptin Phosphate in API and Its Unit Dosage Forms by Spectrophotometry