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The prevalence of obesity is rising worldwide, and presenting a public health problem. Irisin is a novel myokine that is, proteolytically processed from the product of the FNDC5 gene. This study aims at finding out the distribution of FNDC5 rs3480 (A/G) and rs1746661 (G/T) polymorphisms in obese individuals and their association with other clinical and laboratory variables in these persons. This study was done on 141 subjects divided into 2 groups: group I obese group (71) and group II; control group (70). All subjects were submitted to full history taking, general clinical examination and laboratory investigations including BMI, lipid profile, fasting blood glucose, glycated hemoglobin (HbA1c) and genotyping of rs3480 (A/G) and rs1746661 (G/T) gene polymorphisms. There was a significant statistical difference between the two groups regarding genotype frequency of FNDC5 (Irisin precursor) rs3480 (A/G) and rs 174661 (G/T). Regarding rs3480 (A/G), there was a high frequency of AA genotype and A allele among the control group, while GG genotype and G allele had the highest frequency among obese group. Regarding rs1746661 (G/T), there was a high frequency of GG genotype and G allele among the control group, while TT genotype and T allele had the highest frequency among obese group. Multivariate logistic regression for risk of obesity showed that the most common risk factor is BMI OR; 413.9 (6.7-492.6), followed by HBA1C OR; 67.1 (0.72-256.8), Tc OR; 53.6 (3.8-44.5), LDL-C OR; 26.8 (1.0395.1). Conclusion: Our results indicate that GG genotype and G allele of rs3480 (A/G) polymorphism and TT genotype and T allele of rs1746661 (G/T) might be genetic risk factor for obesity.

Irisin Gene Polymorphism Rs3480 and Rs1746661and Obesity in Egyptian Populations