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Background: Thyroid dysfunction is one of the most common endocrinological disorders. Consequently, abnormalities of these hormones frequently involve many organ systems producing diverse clinical signs and symptoms which are generally nonspecific. Thus confirmation of a provisional diagnosis of thyroid disorder rests largely upon the biochemical parameters. Aspartate transaminase (AST) is an enzyme found in nearly all living cells. Aim: This study is conducted to see the effects of variation in thyroid hormones on the Aspartate transaminase (AST) levels, thus elucidating the effect on numerous systems of the body. The study was conducted in the Government Medical College and associated group of Hospitals, Kota (Rajasthan), India. The duration of study was January 2016 to October 2016. The present study comprised of 150 subjects,out of which 50 were hypothyroid and 50 cases of hyperthyroidism and 50 were euthyroid subjects. The statistical analysis was performed by using Microsoft Excel Program. Results: Among the total 150 subjects included in the study, there were 45 males and 105 females. On the basis of Serum T3, T4 and TSH levels, the subjects were categorised into hypothyroid, hyperthyroid and euthyroid. The Mean ± SD of Serum AST levels in hypothyroid, hyperthyroid and euthyroid subjects is 64.28±10.56, 52.08±8.62 and 20.06±8.64 respectively. The results were compared by one way ANOVA. The P value was calculated and found < 0.05, which was considered statistically significant. Conclusion: This study shows the raised levels of AST were seen in hypothyroid and hyperthyroid cases as compared to euthyroid subjects, though the rise is significant in the hypothyroid cases.

A Comparative Study of Serum Ast/Sgot Levels Among the Patients of Thyroid Disorders