English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background: Hepatocellular carcinoma (HCC) is the third most common cause of cancer mortality worldwide. Oncologists depend on AFP as the commonest and feasible marker for assessing HCC in addition to imaging. However, AFP is not completely a reliable marker in early HCC diagnosis due to its low specificity and sensitivity. Objective: evaluation of serum levels of monocyte chemo attractant protein-1 (MCP-1), talin-1& insulin like growth factor-1(IGF-1) in Egyptian patients with HCC compared to liver cirrhosis& healthy controls and to find their values in HCC prediction. Subjects and methods: Subjects sharing were classified as follows: 25 patients with liver cirrhosis, 39 patients suffering from HCC on top of liver cirrhosis in addition to 24 apparently healthy subjects as control group. They were subjected to complete physical examination, routine biochemical tests, radiological examination, serum AFP, taline-1, MCP-1 & IGF-1 determinations. Results: high significant increases in the serum level of talin-1 in HCC patients in comparison with both cirrhotic and control groups. Also, there was a high significant increase in cirrhotic patients compared with the controls. Serum MCP-1 levels were significantly higher in the HCC group than in the cirrhotic group or the controls. However, no significant difference was found between cirrhotic and control groups.the highest sensitivity for detection of HCC was in the favor of MCP-1 (100%), while the highest specificity was taline1(100%). Conclusion: our findings support the potential role of MCP-1 & taline-1 in as screening markers for HCC in cirrhotic patients. The early detection of HCC and discrimination of malignant from the cirrhotic cases is a challenge for the oncologists so, continuous and regular monitoring systems using MCP-1 or the combination of taline-1 with AFP could improve the diagnostic performance over AFP alone in the early detection of HCC in patients with liver cirrhosis.

Evaluation of Taline-1, MCP-1 and IGF-1 in Prediction the Risk of Developing Hepatocellular Carcinoma in Patients With Liver Cirrhosis