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Lead is highly toxic naturally occurring element that affects numerous organ systems in humans. Present study was designed to investigate the preventive role of T. terrestris root extract and vitamin C against lead acetate induced testicular toxicity in Swiss albino mice. Animals exposed to lead acetate at a dose level of 10 mg/kg b.wt. subcutaneously showed significant decrease in protein, sialic acid, ascorbic acid, total thiols and ATPase activity but a significant increase was observed in cholesterol level. These modulatory effects of lead acetate were prevented by concurrent daily administration of T. terrestris root extract. The antioxidant and chemoprotective activity of T. terrestris root extract was compared with vitamin C.

Lead acetate induced oxidative stress and its possible reversal by Tribulus terrestris root extract in testes of Swiss albino mice