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There is a considerable dispute over use of different techniques for prevention of hypotension during caesarean section. Spinal Anesthesia induced hypotension in obstetric patients is still a challenge for many anaesthesiologists as it may lead to complications like reduced utero-placental blood flow leading to fetal acidosis. Aims: The aim of the present study is to compare the effects and side effects of ephedrine administered via two different routes, that is intravenous and intramuscular route. Methods and materials: Institutional Ethics Committee approval was taken before the commencement of the study. An informed and written consent was taken from every patient selected for the study. A randomized study was done on 60 parturient aged between 20-30years, divided into Group IM (n=30) where intramuscular ephedrine 30 mg given 10 min prior to spinal anaesthesia and Group IV (n=30) where intravenous ephedrine 12 mg given at the time of spinal anaesthesia. After intravenous preloading(1015 ml/kg), spinal anaesthesia was given, baseline maternal heart rate and arterial blood pressure were recorded before induction and every 2 min for first 10 min and thereafter every 5 min for 45 min. Results: Mean age of patients in group IM and Group IV was 23.03±2.37 and 24.47±2.25 years respectively (p>0.05). In the intramuscular group, the fall in mean blood pressure after spinal anesthesia was hardly about 10% of the preoperative blood pressure. In the intravenous group, there was a fall in the blood pressure after spinal anesthesia for a short period of time which was statistically significant (p<0.05). Conclusion: Prophylactic use of intramuscular ephedrine in parturient prevents hypotension when compared to intravenous ephedrine during caesarean section.

iosr journal of dental and medical sciences

Comparative study between pre-emptive intramuscular ephedrine and intravenous ephedrine to prevent hypotension during spinal anaesthesia in caesarean section