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Vitamin B12, a water soluble vitamin plays a pivotal role in DNA synthesis, Haemopoesis and maintenance of functional integrity of nervous system. A known pharmacological cause of Vitamin B12 deficiency is prolonged use of Metformin. This study intends to estimate and compare the Vitamin B12 levels among Type2 DM patients with or without Metformin. Materials And Methods: A cross-sectional observational study of 227 patients divided into 121 patients on Metformin monotherapy and 106 patients on other oral hypoglycemic agents and Insulin monotherapy or combination therapy. Clinical examination and laboratory investigations including serum Vitamin B12 levels Was Conducted. Result And Analysis: The Mean Vitamin B12 level among the Metformin Group was 523±231 pg/ml where as that in the Non-metformin group was 598±222 pg/ml. The difference was statistically significant (P=0.01, T=2.5). The serum Vitamin B12 levels showed a negative co-relation with daily dose of Vitamin B12 (P=0.00). Conclusion: Long term use of Metformin predisposes to Vitamin B12 deficiency among Type 2 DM patients.A multi centre population based longitudinal analysis by future researchers is estimated to be further productive.

iosr journal of dental and medical sciences

A Cross Sectional Study to Assess the Prevalence of Vitamin B 12 Deficiency Among Type 2 Diabetes Mellitus Patients on Metformin Therapy in A Tertiary Care Hospital in Eastern India.