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Purpose: The most common etiological agents for hepatocellular carcinoma (HCC) are hepatitis B virus (HBV) and hepatitis C virus (HCV). The present study was aimed to assess the seroprevalence of hepatitis B surface antigen (HBsAg) and antibodies to HCV among patients with HCC, attending a cancer hospital. Method: A retrospective study of patients with histologically and radiologically proven HCC between July 2014 and April 2016 were evaluated for HBsAg and anti-HCV antibodies by Enhanced Chemiluminescence Immuno Assay (CLIA) method using the VITROS ECi/ECiQ Immunodiagnostic systems. Result: Out of 116 HCC patients, 34 (29.31%) were having HBsAg positivity and HCV positivity was seen in 15(12.93%). Co-infection by HCV and HBV was found in 3 (2.58%) patients. Males are affected more than females and most of them are in their fifth or sixth decade. Alpha feto protein levels were higher in 85(73.27%) of patients and serum aminotransferase levels are higher than the reference range. Conclusion: The high seropositivity of HBV and HCV in HCC suggests their role as the causative agents of Hepatocellular carcinoma.

Prevalence of Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) In Hepatocellular Carcinoma Patients Attending A Cancer Hospital