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Acute ischemic stroke (AIS) has several risk factors; atherosclerosis of vessels is the most important one. Atherosclerosis being an inflammatory condition is associated with raised serum level of CRP. Hence the possible role of serum CRP in pathogenesis of AIS is being studied. Many studies support that serum CRP is a marker of stroke severity and prognosis. Material and methods: The present study ‘Serum C-reactive protein in Acute Ischemic stroke and its impact on stroke severity and prognosis’ was carried out at Department of medicine, RIMS Ranchi, India during august 2015 to august 2016. Total 50 neuroimaging confirmed cases of AIS were selected randomly for this noninterventional prospective study. Serum CRP was measured in all patients and NIHSSS was used for assessing stroke severity. Results: The mean CRP level was 21.93∓3.60 mg/l and only 18% of cases were having normal CRP level. 60% of cases were having serum CRP level in the range of 3-30mg/L and 18% were having even the higher level.Age of the patient significantly correlated with the CRP level (r=0.294 at p-0.05) but the sex didn’t affect the rise in CRP (p= 0.490). Serum CRP level was affecting the stroke severity significantly (r=0.643, p-0.000).The mean CRP level in discharged patients was 10.51 ∓ 13.21 mg/l whereas it was 44.11 ∓ 29.7 mg/l in those who died in the hospital. Thus CRP level affected mortality of acute ischemic stroke significantly. (p-0.00). Conclusion: CRP is raised in most of the patients of acute ischemic stroke and its elevation reveals the underlying inflammation causing atherosclerosis as well as CRP as a marker of brain injury. Serum C-reactive protein elevation is associated with more severe stroke and poor prognosis.

Study of Serum C-Reactive Protein In Acute Ischemic Stroke And Its Impact on Stroke Severity And Prognosis.